Symbol
Name
ID

Traf2
TNF receptor-associated factor 2
MGI:101835

Phenotype annotations related to immune system

Darker colors indicate more annotations

Mouse Phenotypes

increased thymocyte apoptosis

thymus atrophy

decreased thymocyte number

enlarged spleen

decreased immature B cell number

decreased double-positive T cell number

increased granulocyte number

decreased mature B cell number

absent follicular B cells

absent marginal zone B cells

increased follicular B cell number

increased marginal zone B cell number

increased B cell number

decreased CD8-positive, alpha-beta T cell number

decreased alpha-beta T cell number

decreased lymphocyte cell number

abnormal spleen morphology

spleen atrophy

absent spleen germinal center

abnormal spleen marginal zone morphology

abnormal B cell physiology

increased circulating tumor necrosis factor level

absent lymph node germinal center

enlarged lymph nodes

lymph node hyperplasia

lymphoid hypoplasia

Availability

Mouse Genotype

Traf2^tm1Mak/Traf2^tm1Mak

Traf2^{tm1a(EUCOMM)Wtsi}/Traf2⁺

Tg(Mx1-cre)1Cgn/0
Traf2^tm1Rbr/Traf2^tm1Rbr (conditional)

Cd19^tm1(cre)Cgn/Cd19⁺
Traf2^tm1Rbr/Traf2^tm1Rbr (conditional)

Tg(Lck-cre)I57Jxm/?
Traf2^tm1Rbr/Traf2^tm1Rbr (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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